Nilda’s research into leukaemia and heart failure
Nilda Ilker
Nilda’s journey into cancer research began during her undergraduate degree in Biochemistry with a Year in Industry at University of East Anglia (UEA), which later led to her pursuing a PhD looking at leukaemia and heart failure.
Her interests deepened through hands-on experiences at Quadram Institute Bioscience (QIB), where she spent both her placement year and a full year post-graduation as a Project Scientist in Dr Stephen Robinson’s lab.
Her time at QIB exposed her to research and gave her confidence in pursuing a PhD. It was also where she encountered Big C for the first time, working alongside two PhD students funded by the charity.
“The lab experience was integral to choosing whether I wanted to do a research degree” Nilda says.
Bridging two worlds
“Having heard the studentships available with Big C funding, I decided to apply and was excited to be given the opportunity.“
With support from Big C, Nilda started undertaking a PhD at the University of East Anglia, investigating the metabolic link between acute myeloid leukaemia (AML) and heart failure. This was a perfect blend of her two scientific interests.
“This project brought together cancer research and cardiovascular disease, two areas I had developed a deep interest in.”
The research: How AML might harm the heart
Chemotherapy is known to negatively affect heart health. Patients with acute myeloid leukaemia (AML) – a form of blood cancer, have been found to shown markers of heart failure even before treatment begins. This startling discovery raises the question: could AML itself be driving changes in the heart?
Nilda’s research focuses on how leukaemia cells may send harmful signals from the bone marrow to the heart, altering heart cell function and ultimately contributing to heart failure.
“If we can understand this link, we may help not just AML patients that suffer from heart disease, but possibly those affected by other types of leukaemia too.”
Scientific challenges
The novelty of her research means there are few established methods to draw on, which she has found challenging. “Some experimental techniques are so new, there’s very little literature to rely on,’ she says. “Perfecting them takes time, but the potential impact is worth it.“
Beyond the lab: Engaging with Big C
As a Big C supported student, Nilda has valued opportunities to connect beyond academia. She’s taken part in public engagement activities, including running the Big C stall at the Norwich Science Festival, alongside fellow PhD students and volunteers.
“Research can sometimes feel isolating, but connecting with the public reminds you why your work matters.”
Looking ahead
Nilda is currently optimising experimental techniques and looks forward to gathering exciting results.
Her work could provide vital insight into a little-understood area of cardio-oncology, with the potential to shape better treatments and improve long-term outcomes for people affected by blood cancers.
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