Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

Tumour repression

Tumour repression

Preventing tumour progression

£83,152 in autumn 2013 over 3 years to the School of Chemistry, University of East Anglia

WWP2 is an enzyme involved in signalling within cells.  It determines whether the cell will multiply by binding to other proteins and changing their behaviour.  Several of the proteins it interacts with are involved with tumour formation and cell proliferation, and activating WWP2 can make cells multiply faster.

Big C has previously funded work on WWP2, and this new grant will fund a PhD student for 3 years to study WWP2 binding interactions.  Binding can cause small or large changes in the shape of WWP2, and a technique called Nuclear Magnetic Resonance (NMR) can track these changes to give information about what WWP2 binds to and how this happens.  Once this information has been collected, the next stage of the project will involve designing small molecules that will interfere with binding.  Molecules that prevent binding could lead to new drugs that reduce or prevent tumour growth.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.