Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

The interplay of dietary polyphenols and gut microbiota in mammary tumourigenesis and metastasis

The interplay of dietary polyphenols and gut microbiota in mammary tumourigenesis and metastasis

2018 Research Grant Award

Funding requested: £95,300 | Funding awarded: £94,300 for a 36 month PhD to start September 2019 at Norwich Medical School, UEA.

Grant Applicants:

Dr Stephen Robinson

Dr Lindsay Hall (QIB) (co-applicant)

Professor Cathie Martin (JIC) (co-applicant)

Professor Dylan Edwards (QIB) (co-applicant)

Breast cancer affects 1 in 8 women in the UK and is a leading cause of cancer mortality.  Its incidence is rising, potentially due to increasing population age but also due to effects of diet and lifestyle.  Data from large-scale population studies indicate the benefits of diets rich in plant-derived polyphenolic compounds but experimental data on how these protective effects have been elusive.

Recent work from the co-applicants Drs Lindsay Hall and Stephen Robinson have demonstrated a key role for the microbes that reside in our digestive systems (gut microbiota) in influencing the development of breast cancer in mice under experimental conditions.  They do this via effects on the immune system – essentially the gut microbes “educate” the immune system.

Co-applicant Prof Cathie Martin has generated a suite of experimental tomato strains enriched for the production of specific molecules that are thought to be responsible for the health promoting properties of certain plants and the things we produce from them – eg, red and purple berries, red wine, soy etc.  Diets based on these enriched tomato lines have been shown to influence the gut microbiota ecosystem and reduce the symptoms of inflammatory bowel disease.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

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Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.