Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

Protease function in breast cancer

Protease function in breast cancer

£66,006 in autumn 2008 to the School of Biological Sciences at the UEA for a 3 year project to investigate the function of protease enzymes in breast cancer.

Proteases are proteins whose job is to cut other proteins – essentially they act like molecular scissors.  It had been thought that proteases released from cancer cells were able to cut up the molecules surrounding the cells, clearing the path for malignant cells to invade neighbouring tissues. However, looking at human tumours shows that a protease known as MMP8 is in fact associated with a good outcome in breast cancer: patients whose tumours had higher levels showed less spread of the tumours to lymph nodes and improved survival.

This work has been repeated in other systems and MMP8 is now known to be a tumour suppressive protease. Its cutting action is essential for it to stop tumours spreading, so the next step is to identify what it cuts. This will help explain its action and could identify new molecules that prevent tumour spread – the main cause of cancer patient death.  This project will provide 3 years support to train a PhD student in research methods, which it is hoped will lead to important new discoveries on the basic mechanisms of cancer.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.