Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

Investigating a DNA mutation caused by UV radiation

Investigating a DNA mutation caused by UV radiation

DNA damage from UV radiation

£50,161 in spring 2009 for a 1 year project at the School of Biological Sciences at UEA, investigating a DNA mutation caused by UV radiation.

Malignant melanoma is a devastating form of skin cancer caused by uncontrolled growth of skin pigment cells known as melanocytes.  The only effective cure is surgical removal.

Studies suggest that exposure to sunlight and ultraviolet radiation is one of the major contributors to the development of melanoma.  UV radiation causes damage to the DNA of cells, causing mutations in skin cell genes. One such mutation has recently been found to occur in a gene known as WWP2, which normally acts to prevent melanoma outgrowth and migration to other tissues.

The project aims to understand how this mutation causes normal skin cells to undergo the transition to malignant melanoma.  This could allow the development of inhibitor drugs that block tumour-causing activity, providing new hope for the treatment of aggressive late-stage skin cancers.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.