2018 Research Grant Award
Funding requested: £20,121 | Funding awarded: 50% (£10,060) of total cost to be offered subject to match funding being secured by the applicant. The Lilac Ladies (A fundraising group in support of Big C) to fund Big C’s 50% at the School of Biological Sciences, UEA.
Dr Mette Mogensen
Dr Paul Thomas (co-applicant)
We need to understand how cancer cells migrate and spread in order to determine whether compounds such as sulforaphane, found in broccoli and other cruciferous vegetables, can be used in the prevention and treatment of cancer.
Live imaging of filaments in side cells that drive movement help us to understand the processes involved. This is especially so for our current study on the molecule Rap1GAP which acts on these filaments and inhibits the spread of cancer. Rap1GAP is decreased in many cancers allowing them to spread.
Excitingly, our recent findings suggest that the compound sulforaphane can reverse this and increase the amount of Rap1GAP present in cancer cells thus reducing the spread of cancer. In order to receive very good quality live images of cancer cells we need a high resolution, sensitive and fast camera such as the requested Hamamatsu Orca-Flash 4.0 V3. In addition, a special software programme called Huygens would further enhance details in the acquired images. Our current camera is 15 years old and lacks the sensitivity and speed required for detailed live-imaging. The Hamamatsu Orca-Flash 4.0 V3 camera and “Huygens” deconvolution software would therefore greatly benefit our cancer research as well as that of others on the NRP.