Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

High resolution and fast live time-lapse imaging of fluorescent-tagged proteins in cancer cells

High resolution and fast live time-lapse imaging of fluorescent-tagged proteins in cancer cells

2018 Research Grant Award

Funding requested: £20,121 | Funding awarded: 50% (£10,060) of total cost to be offered subject to match funding being secured by the applicant. The Lilac Ladies (A fundraising group in support of Big C) to fund Big C’s 50% at the School of Biological Sciences, UEA.

Grant Applicants:

Dr Mette Mogensen

Dr Paul Thomas (co-applicant)

We need to understand how cancer cells migrate and spread in order to determine whether compounds such as sulforaphane, found in broccoli and other cruciferous vegetables, can be used in the prevention and treatment of cancer.

Live imaging of filaments in side cells that drive movement help us to understand the processes involved. This is especially so for our current study on the molecule Rap1GAP which acts on these filaments and inhibits the spread of cancer. Rap1GAP is decreased in many cancers allowing them to spread.

Excitingly, our recent findings suggest that the compound sulforaphane can reverse this and increase the amount of Rap1GAP present in cancer cells thus reducing the spread of cancer. In order to receive very good quality live images of cancer cells we need a high resolution, sensitive and fast camera such as the requested Hamamatsu Orca-Flash 4.0 V3. In addition, a special software programme called Huygens would further enhance details in the acquired images. Our current camera is 15 years old and lacks the sensitivity and speed required for detailed live-imaging. The Hamamatsu Orca-Flash 4.0 V3 camera and “Huygens” deconvolution software would therefore greatly benefit our cancer research as well as that of others on the NRP.

Take me to a different section...

Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.