2017 Research Grant Award
£80,977 for a 36 month PhD project to start 1 Oct 2018 at Norwich Medical School, Bob Champion Research and Education Building, UEA.
Dr Dan Brewer
Professor Colin Cooper
Cancer is not a disease but a collection of diseases in different tissues. Even within a single cancer type such as breast cancer, dividing up the disease into sub-types is important to help predict survival, inform treatment options and suggest new drug treatment strategies to improve the lives of those affected by cancer. Due to technological advances we now have measurements on the amounts of all genes expressed in cells of a large number of cancer samples. Unfortunately determining subtypes has been largely unsuccessful using traditional techniques with the notable exception of breast cancer.
We have applied an alternative computerised approach to finding subtypes in prostate cancer. This approach is called LPD and it has successfully identified a particular subtype we call DESNT which is associated with a poor prognosis for patients. In this project we plan to apply LPD to data from the Cancer Gene Atlas, a large US project that has generated comprehensive multi level datasets in a large number of cancer types. These studies are expected to identify and characterise new sub types for many cancers. We will also train a cross disciplinary scientist who can understand and interpret both cancer and mathematical procedures necessary to continue cancer research in this era of big data and personalised medicine.