Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

Detecting novel cancer sub-types in the Cancer Genome Atlas datasets using latent process decomposition

Detecting novel cancer sub-types in the Cancer Genome Atlas datasets using latent process decomposition

2017 Research Grant Award

£80,977 for a 36 month PhD project to start 1 Oct 2018 at Norwich Medical School, Bob Champion Research and Education Building, UEA.

Grant Applicants:

Dr Dan Brewer

Professor Colin Cooper

Cancer is not a disease but a collection of diseases in different tissues. Even within a single cancer type such as breast cancer, dividing up the disease into sub-types is important to help predict survival, inform treatment options and suggest new drug treatment strategies to improve the lives of those affected by cancer. Due to technological advances we now have measurements on the amounts of all genes expressed in cells of a large number of cancer samples. Unfortunately determining subtypes has been largely unsuccessful using traditional techniques with the notable exception of breast cancer.

We have applied an alternative computerised approach to finding subtypes in prostate cancer. This approach is called LPD and it has successfully identified a particular subtype we call DESNT which is associated with a poor prognosis for patients. In this project we plan to apply LPD to data from the Cancer Gene Atlas, a large US project that has generated comprehensive multi level datasets in a large number of cancer types. These studies are expected to identify and characterise new sub types for many cancers. We will also train a cross disciplinary scientist who can understand and interpret both cancer and mathematical procedures necessary to continue cancer research in this era of big data and personalised medicine.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.