Support

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

Colon cancer diagnosis

Colon cancer diagnosis

Centrosome organisation in colon cancer

£73,653 in autumn 2008 to the School of Biological Sciences at the UEA for a 3 year project to study a possible marker for colon cancer diagnosis.

Microtubules are rigid hollow rods that influence the shape and movement of cells, and are essential for many functions. In most animal cells a structure called the centrosome is responsible for the formation and organisation of microtubules. Many cancer cells have a defective centrosome.

A centrosome protein called ninein is very important for organising microtubules. Abnormal distribution of ninein is likely to lead to a disorganised microtubule network. Preliminary data on colon cancer cells suggest that ninein is dispersed throughout the cell and that the microtubules are highly disorganised.

This project aims to determine whether ninein distribution is abnormal in colon cancer cells generally and whether this is linked to the presence of disorganised microtubules. It will also determine whether ninein could potentially prove to be valuable as a marker for diagnosing colon cancer.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.