Enzymes and cell signalling

Investigation into the interaction and signalling of cells

Autumn 2010

£70,578 for a three year research project into cellular interaction by the School of Biological Sciences at the University of East Anglia.

Adam-15 is a protein found as different variants in the body, these variants tend to produce different outcomes; variants A and B are associated with poorer outcomes in patients whose cancer hasn't spread to the lymph nodes while variant C is associated with a better outcome for those whose cancer has.

This study will look at the interactions between variants A, B and C as well as two intercellular signalling proteins called Src and Brk. A better understanding of the complex relationships between the variants may allow for the selective blocking of certain signals and therefore allow for future therapy developments.

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