Restricting Tumour Growth (2)

Reducing the effects of drug resistance
Winter 2014

£104,876 to the School of Biological Sciences at UEA for a project to look at changes that occur in blood vessels following a long course of cancer treatment.

Solid tumours need a blood supply to be able to grow. Without it they are limited to about 2mm in size, or cells at the centre of the tumour begin to die from oxygen starvation. The formation of a new blood supply, a process known as angiogenesis, can also help cancer spread to new sites in the body; the new blood vessels are usually leaky, giving the cancer cells access to the body’s circulation. This role means that angiogenesis is a good target for drugs designed to limit cancer growth.

Some of the most promising drugs block a protein called αvβ3-integrin that is required for blood vessels to move towards a growing cancer. Unfortunately in many patients these drugs only work for a short period of time before their cancer becomes resistant. Big C helped fund previous work by this research group that identified changes to blood vessels that have had αvβ3-integrin production blocked for a long period of time. This project will study these changes and test whether any of them can be targeted to improve the success of anti-angiogenesis treatments and increase patient survival.

Big C can only continue to fund projects like this with help from our local donors. Can you help? Click HERE to find out how you can help projects like this happen. .