Drug resistance

Investigating cell resistance to drug treatments

Spring 2008

£29,928 to the School of Chemical Sciences and Pharmacy at UEA to study the resistance of cancer cells to drug treatments.
Recovery rates from acute myeloid leukaemia (AML) are limited by resistance to existing drug treatments as AML cells produce unusually high levels of an antioxidant enzyme called HO-1.   Preventing production of this enzyme in AML cells causes them to revert back to their normal levels of sensitivity. 
This study hopes to determine whether HO-1 plays a similar role in other cancers such as lymphoma and other forms of leukaemia.  If this is the case, this knowledge will enable the development of methods to prevent the production of HO-1, and this in turn may improve sufferer survival rates.


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