IDO enzyme inhibition

Synthesis of new enzyme inhibitors

Autumn 2009
 
£50,893 for a 1 year project to investigate enzyme inhibition in the School of Chemical Sciences, University of East Anglia.

IDO is an enzyme involved in the degradation of the essential amino acid tryptophan.  Cancerous cells usually have an increased level of IDO, and the resulting decrease in tryptophan this causes is a contributing factor in cancer.  Work previously funded by Big C studied the interaction between IDO and tryptophan. 

This project aims to build on previous work to synthesize and characterize new molecules that can inhibit IDO activity, and test their effects on cancer cells grown in culture.  These could be then used as a starting point for developing new therapeutic molecules. 

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