Investigation into the enzyme IDO

Studies of a cancer-related enzyme

Spring 2007

£40,356 to the School of Chemical Sciences and Pharmacy at UEA for a project to investigate the enzyme IDO.
 
IDO is a protein present in most human cells.  Cancerous cells make much more IDO than normal cells, and this IDO in cancer cells is one of the reasons cancer spreads.  A drug that interferes with how IDO operates might be a target for drug therapy for treating many kinds of cancer. 

This project will study IDO to help with the design of possible drugs that interfere with it.  The main technique used, Nuclear Magnetic Resonance spectroscopy (NMR) is related to the magnetic resonance imaging (MRI) body scanners used in hospitals to assist in clinical diagnosis.  MRI provides three-dimensional images of bodies and NMR three dimensional images of proteins interacting with drugs.  The goal is to obtain a picture of how possible drugs bind to IDO in order to help with future design.

 

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