laboratory

Cell protection

Understanding chemotherapy resistance

Autumn 2012

£53,173 to the School of Pharmacy, UEA

Multiple myeloma (MM) is a blood cancer in which abnormal plasma cells accumulate in the bone marrow. Cells have a selection of genes called cytoprotective genes which help the cell defend itself against chemical attack.  These protective genes make the cancer cells more difficult to kill, possibly requiring much higher doses of chemotherapy.

This grant funds a project that aims to characterise the role played by cytoprotective genes in MM drug resistance.  The last 10 years have seen important advances in the treatment of MM, but it remains difficult to treat, with a survival rate after 5 years of about 40%1. A better understanding of the biology of drug resistance could improve existing treatments and allow the design of new ones.

1Office of National Statistics


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