Research into the beginnings of bowel cancer

Studying the initiation of colon cancer

Autumn 2009

£63,944 for a 1 year project to study the beginnings of colon cancer in the School of Biological Sciences at UEA.

Bowel cancer is the third most common cancer in the UK.1 It is treated by a combination of surgery, chemotherapy and radiation.

Cells respond to their environment and communicate with each other via a network of signalling pathways.  Recently there has been an explosion of information on the pathways that are altered to initiate colon cancers.  This project will study these and test the hypothesis that high levels of prostaglandin E2 (a molecule involved in inflammation) can combine with pathways already known to be involved in cancer to stimulate the growth of colon cancer cells.

This strategy will allow the identification of components that can be targeted in new strategies to prevent colon cancer initiation and progression.

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1Office of National Statistics